TCM-ID Prescription

Prescription Description

Prescription ID	TCMFx6585
Pinyin Name	Zhi Sou Ke Chuan Ning Tang Jiang
Chinese Name	æ¢å—½å’³å–˜å®ç³–æµ†
English Name	Zhi Sou Ke Chuan Ning Syrup
Function Description	å’³å—½, å–˜ç—…
Indications	Dyspnea
Disease ICD-11 Category	MD11.5 [Dyspnoea, å‘¼å¸å›°éš¾ ];
Human Tissues Associated with Indication	Lung
Reference	CFDA
Reference Book/link	http://samr.cfda.gov.cn/WS01/CL0001/

Prescription Components

Component ID	Latin Name	Chinese Name	Component Quantity	Barcode
TCMH456	Rhizoma dioscoreae nipponicae	åœ°é¾™	TCMH456
TCMH986	Scutellaria baicalensis	é»„èŠ©	TCMH986	ITSAP4211-14
TCMH1219	Semen armeniacae amarum	è‹¦æä»	TCMH1219
TCMH552	Rhizoma pinelliae preparata	æ³•åŠå¤	TCMH552
TCMH191	Mentha haplocalyx	è–„è·æ²¹	TCMH191	HM595443
TCMH2515	Papaver somniferum	ç½‚ç²Ÿå£³	TCMH2515	ITSAD207-14
TCMH2725	Fructus perillae	ç´«è‹å	TCMH2725

Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID	Gene Symbol	Target Name	Target Class	Uniprot ID
TCMT112	ADORA3	Adenosine A3 receptor	GPCR	P0DMS8
TCMT113	OPRD1	Delta opioid receptor	GPCR	P41143
TCMT116	OPRM1	Mu opioid receptor	GPCR	P35372
TCMT117	OPRK1	Kappa opioid receptor	GPCR	P41145
TCMT127	PARP1	Poly [ADP-ribose] polymerase-1	Transferase	P09874
TCMT128	TNKS2	Tankyrase-2	Transferase	Q9H2K2
TCMT129	TNKS	Tankyrase-1	Transferase	O95271
TCMT131	ACHE	Acetylcholinesterase	Hydrolase	P22303
TCMT133	CA1	Carbonic anhydrase I	Lyase	P00915
TCMT134	CA2	Carbonic anhydrase II	Lyase	P00918
TCMT136	CA12	Carbonic anhydrase XII	Lyase	O43570
TCMT138	CA7	Carbonic anhydrase VII	Lyase	P43166
TCMT142	CA4	Carbonic anhydrase IV	Lyase	P22748
TCMT156	CYP19A1	Cytochrome P450 19A1	Oxidoreductase	P11511
TCMT160	HTR7	Serotonin 7 (5-HT7) receptor	GPCR	P34969
TCMT162	UGT1A1	UDP-glucuronosyltransferase 1-1	Transferase	P22309
TCMT215	CYP1A1	Cytochrome P450 1A1	Oxidoreductase	P04798
TCMT219	CYP1A2	Cytochrome P450 1A2	Oxidoreductase	P05177
TCMT223	AKR1B1	Aldose reductase	Oxidoreductase	P15121
TCMT232	ABCB1	P-glycoprotein 1	Transporter	P08183
TCMT240	AMY1A	Salivary alpha-amylase	Unclassified	P04745
TCMT254	CBR1	Carbonyl reductase [NADPH] 1	Oxidoreductase	P16152
TCMT257	CYP1B1	Cytochrome P450 1B1	Oxidoreductase	Q16678
TCMT27	DRD1	Dopamine D1 receptor	GPCR	P21728
TCMT283	PTPRS	Receptor-type tyrosine-protein phosphatase S	Hydrolase	Q13332
TCMT295	MMP1	Matrix metalloproteinase-1	Hydrolase	P03956
TCMT297	FABP4	Fatty acid binding protein adipocyte	Unclassified	P15090
TCMT298	FABP3	Fatty acid binding protein muscle	Hydrolase	P05413
TCMT3	ALOX15	Arachidonate 15-lipoxygenase	Oxidoreductase	P16050
TCMT306	MMP2	Matrix metalloproteinase-2	Hydrolase	P08253
TCMT318	HKDC1	Putative hexokinase HKDC1	Transferase	Q2TB90
TCMT321	MMP9	Matrix metalloproteinase 9	Hydrolase	P14780
TCMT34	CYP2D6	Cytochrome P450 2D6	Oxidoreductase	P10635
TCMT36	HTR1A	Serotonin 1a (5-HT1a) receptor	GPCR	P08908
TCMT37	HTR2A	Serotonin 2a (5-HT2a) receptor	GPCR	P28223
TCMT38	DRD2	Dopamine D2 receptor	GPCR	P14416
TCMT384	GRK6	G protein-coupled receptor kinase 6	Kinase	P43250
TCMT592	XDH	Xanthine dehydrogenase	Oxidoreductase	P47989
TCMT615	SENP8	Sentrin-specific protease 8	Protease	Q96LD8
TCMT616	SENP7	Sentrin-specific protease 7	Protease	Q9BQF6
TCMT617	SENP6	Sentrin-specific protease 6	Protease	Q9GZR1
TCMT63	PPARA	Peroxisome proliferator-activated receptor alpha	Nuclear receptor	Q07869
TCMT65	HSD17B1	Estradiol 17-beta-dehydrogenase 1	Oxidoreductase	P14061
TCMT752	CSNK2A1	Casein kinase II alpha	Kinase	P68400
TCMT789	PDE3A	Phosphodiesterase 3A	Hydrolase	Q14432
TCMT790	PDE3B	Phosphodiesterase 3B	Hydrolase	Q13370
TCMT792	PDE10A	Phosphodiesterase 10A	Hydrolase	Q9Y233
TCMT8	KDM4E	Lysine-specific demethylase 4D-like	Oxidoreductase	B2RXH2
TCMT801	TUBB3	Tubulin beta-3 chain	Unclassified	Q13509
TCMT853	SIGMAR1	Sigma opioid receptor	Unclassified	Q99720
TCMT87	CYP2C9	Cytochrome P450 2C9	Oxidoreductase	P11712

Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID	Target Name
TCMT1176	Streptococcus pneumoniae
TCMT1178	Actinomyces viscosus
TCMT1191	Bacillus megaterium
TCMT1212	Verticillium dahliae
TCMT1214	Enterococcus faecium
TCMT1217	Bacillus anthracis
TCMT1218	Staphylococcus aureus
TCMT1221	Human herpesvirus 4
TCMT1223	Staphylococcus epidermidis
TCMT1226	Klebsiella pneumoniae
TCMT1229	Enterococcus faecalis
TCMT1232	Pseudomonas aeruginosa
TCMT1236	Mycobacterium bovis
TCMT1246	Escherichia coli
TCMT1249	Dengue virus 2
TCMT1251	Candida albicans
TCMT1253	Penicillium chrysogenum
TCMT1260	Streptococcus agalactiae
TCMT1286	Bacillus cereus
TCMT1319	Corynebacterium xerosis
TCMT1322	Streptococcus mitis
TCMT1323	Corynebacterium pseudodiphtheriticum
TCMT1324	Corynebacterium diphtheriae
TCMT1346	Helicobacter pylori
TCMT1349	Helicobacter pylori SS1
TCMT1410	Listeria monocytogenes
TCMT1412	Salmonella typhimurium
TCMT1438	Plasmodium falciparum
TCMT1439	Mycobacterium smegmatis
TCMT1442	Leishmania donovani
TCMT1448	Enterobacter aerogenes
TCMT1449	Influenza A virus
TCMT1454	Bacillus subtilis
TCMT1455	Mycobacterium tuberculosis H37Rv
TCMT1458	Filobasidiella neoformans
TCMT1462	Streptococcus mutans
TCMT1464	Hepatitis B virus
TCMT1465	Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term	GO Name	Enriched Genes	Log10 Adjusted P-value

KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID	Enriched Genes	Log10 Adjusted P-value

Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset

Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples

Data Section	Select to Download
1. General Information of Prescription
2. Putative Targets
3. Activity & References for Filtering Putative Targets
4. GO & Pathway

TCM Prescription: Zhi Sou Ke Chuan Ning Syrup